Study the Effect of Ultrasonic Irradiation and Surfactant/Fe ions Weight Ratio on Morphology and Particle Size of Magnetite Nanoparticles Synthesised by co-precipitation for Medical Application
Abstract:A biocompatible ferrofluid have been prepared by coprecipitation
of FeCl2.4H2O and FeCl3.6H2O under ultrasonic
irradiation and with NaOH as alkaline agent. Cystein was also used
as capping agent in the solution. Magnetic properties of the produced
ferrofluid were then determined by VSM test and magnetite
nanoparticles were characterized by XRD and TEM techniques. The
effect of surfactant to Fe ion weight ratio was also studied during this
project by using two different amount of Dextran. Results showed the
presence of a biocompatible superparamagnetic ferrofluid including
magnetite nanoparticles with particle size ranging under 20 nm. The
increase in the surfactant content results in the narrowing of the size
distribution and reduction of the particle size and more solution
 K.L. Ang, S. Venkatraman, R.V. Ramanujan, Mater. Sci. Eng. C 27
 M. Arruebo, R.F. Pacheco, M.R. Ibarra, J. Santamaria, Nanotoday 2
 D.K.Kim, Y. Zhang, J. Kehr, T. Klason, B. Bjelke, M. Muhammed, J.
Magn. Mater. 255 (2001) 256.
 S.Odenbach , Colloids and Surfaces A: Physicochemical and
Engineering Aspects, 217 (2003) 171.
 Dekker, Dekker Encyclopedia of Nanoscience and Nanotechnology,
MARCEL DECCER INC., Vol 2, (2005).
 H. Eifert, D. Kupp and B. Gunther, Powder Metallurgy, 43 (2000) 310-
 H. Hahn, Nanostructured Materials, 9 (1997) 3-12.
 J.M. Markus, Swiss Federal Institute of Technology (ETH), 2000.
 V. R. Parkal, Nanostructured Materials, 11 (1999) 369-374.
 E. Pollerta, S. Vasseur and E. Duguet, J. Magn. Magn. Mater.,
ARTICLE IN PRESS, 2007.
 D.H. Kim, S.H. Lee, K.N. Kim, K.M. Kim, I.B. Shim and Y.K. Lee J.
Magn. Magn. Mater., 293 (2005) 320-327.
 E.H. Kim, Y. Ahn and H.S. Lee, Journal of Alloys and Compounds 434
 V.M. Guilherme, P. Corio and J. Rubim, Journal of Electroanalytical
Chemistry, 603 (2007) 27-34.
 R.Y. Hong, T.T. Pan, Y.P. Han, H.Z. Li, J. Ding and S. Han, J. Magn.
Magn. Mater., 310 (2007) 37-47.
 G. Gnanaprakash, S. Mahadevan, T. Jayakumar, P. Kalyanasundaram,
John Philip and Baldev Raj, Materials Chemistry and Physics, In Press,
Corrected Proof, Available online 20 February 2007.
 T.N. Brusentsova, N.A. Brusentsov, V.D. Kuznetsov and V.N.
Nikiforov, J. Magn. Magn. Mater., 293 (2005) 298-302.
 A. Skumiel, J. Magn. Magn. Mater., 307 (2006) 85-90.
 O.A. Kuznetsova, O.N. Sorokina, V.G. Leontiev, O.A. Shlyakhtin, A.L.
Kovarskia and A.A. Kuznetsov, J. Magn. Magn. Mater., 311 (2007)
 A. Wijaya, K.A. Brown, J.D. Alper and K.H. Schifferli, J. Magn. Magn.
Mater., 309 (2007) 15-19.
 J.K. Yang , J.H. Yu , J. Kim and Y.H. Choa, Materials Science and
Engineering A 449-451 (2007) 477-479.
 A. Bee, R. Massart and S. Neveu, J. Magn. Mater., 149 (1995) 6.
 A.K. Gupta and M. Gupta, Biomaterials, 26 (2005) 3995-4021.
 R.Y. Hong, B. Feng, L.L. Chen, "Synthesis, characterization and MRI
application of dextran-coated Fe3O4 magnetic nanoparticles",
Biochemical Engineering Journal, Article in press, (2008).